4 Steps to the Radiological Diagnosis

What do the CT images show?   List the abnormalities you found in examining the scans
Are there any technical limitations to this examination? Movement, metal, or other artifacts; No bone or subdural windows; No contrast enhancement or no unenhanced views; No coronal projections; No thin slices; etc
What is the significance of these findings in the individual case under review? Correlations with age, gender, clinical signs and symptoms, other imaging and other investigation results.
What is the radiological differential diagnosis for this case? Consider anatomic pathology, pathophysiology, etiology, chronicity. 

 

 

 

 

 

 

 

 

 

 

 

 

 6 Components of the Radiological Diagnosis

Anatomy

     ● Intra-axial or Extra-axial
     ● Focal, Multifocal, or Diffuse
     ● Right or Left or Bilateral
     ● Supratentorial or Infratentorial
     ● White, Grey, or Both
     ● Specific locations

Etiology

     ● Genetic
     ● Developmental
     ● Traumatic
     ● Vascular
     ● Neoplastic
     ●Iatrogenic
     ● Infectious/inflammatory
     ● Immune
     ● Degenerative
     ● Toxic
     ● Metabolic
     ● Etc

Pathology

     ● Infarction
     ● Neoplasm
     ● Hemorrhage
     ● Demyelination
     ● Aneurysm
     ● Etc

Chronicity

     ● Acute
     ● Subacute
     ● Chronic
     ● Recurrent
     ● Residual

Patho-

physiology 

     ● Embolization
     ● Thrombosis
     ● Intracranial hypertension
     ● Ischemia
     ● Hypoxia
     ● Infiltration
     ● Herniation
     ● Etc

Differential

 Diagnosis

List of several possible pathologies

 

 

 

 

 

 

 


Some concepts useful in analyzing CT scans of the brain

Some radiological diagnoses are demonstrated (e.g. hydrocephalus, intracerebral hematoma), some suspected (e.g., aqueduct stenosis, aneurysm rupture).

Particular areas are prone to particular sorts of pathology. Middle cerebral aneurysms occur in the Sylvian fissure, acoustic neuromas in the internal auditory canal.

Density can be measured in Hounsfield Units on the screen but is usually judged visually in relationship to the tissues around the area in question. Common hyperdensities include: blood, calcification or mineralization, foreign bodies, enhancing lesions such as tumours and subacute infarctions and contusions. Common hypodensities include: edema, non-enhancing tumours, infarctions, air, chronic hematoma.

Mass effect is very important to note. There may not always be a midline shift if the process is generalized but compression of CSF cisterns and sulci will be evident.

Vascular territories are quite typical so wedge shaped hypodensities can often be attributed to specific vessels.

White matter disorders are confined to the white matter and grey matter diseases are confined to the grey matter. Tumours, trauma, bleeds, infarctions, etc do not confine themselves to one or the other.

Artifact can sometimes explain the otherwise unexplainable. There can be movement artifact, metal object induced artifact, and the work of trolls or gremlins in the CT machine.

 

 

 

 

 

Links to Useful Web Sites
Brain Lesion Locator Brain Lesion Locator ™: Differential Diagnosis by Location James G. Smirniotopoulos, M.D. Uniformed Services University of the Health SciencesBethesda, MD
Anatomy Guide Anatomy Guide component of this web site
Lobes etc Illustrated on MRI Scans from Neuroradiology tutor designed by Kevin Ketchum at the University of Wisconsin Medical School. Go to Cerebral Cortex and try the axial series!!
MRI's with Anatomic Labels from The Whole Brain Atlas by Keith A. Johnson, M.D. (keith@bwh.harvard.edu) and J. Alex Becker (jabecker@mit.edu)
Regional Neuroanatomy & Differential Diagnosis

James G. Smirniotopoulos, M.D. Uniformed Services University of the Health SciencesBethesda, MD

Neoplasm Imaging Characteristics Collaborative Hypertext of Radiology
Gross Path correlated with Imaging The Internet Pathology Laboratory for Medical Education from Florida State University College of Medicine